Latest

Pain

Pain Neuroscience news articles cover science research about pain receptors, nociceptors, nociception, sensory neurons, somatosensory cortex, chronic pain, acute pain, nocioceptors, musculoskeletal pain, therapies, phantom limb pain and other pain research.

Featured Neurology Neuroscience Pain

·May 17, 2025·4 min read

Tylenol Targets Pain Through Unexpected Endocannabinoid Pathway

A new study reveals that acetaminophen (Tylenol) relieves pain by reducing levels of an endocannabinoid called 2-AG, rather than increasing it as previously thought. This discovery challenges decades-old assumptions about how pain relief works and may open the door to designing safer, more targeted medications.

This shows a foot radiating red light, symbolizing pain.

Featured Genetics Neurology Neuroscience Pain

·May 13, 2025·7 min read

Century-Old Mystery May Hold the Key to Diabetic Nerve Pain

A little-known cellular structure called the Nageotte nodule—first described over 100 years ago—has been identified as a key feature of diabetic neuropathy in new research. These nodules, made of decayed sensory neurons and support cells, were found in abundance in the sensory ganglia of diabetic organ donors.

Featured Neurology Neuroscience Pain

·May 7, 2025·5 min read

Gut Microbiome Reveals Chronic Pain Risk, AI Study Finds

New research shows that AI can identify complex regional pain syndrome (CRPS) with over 90% accuracy by analyzing gut microbiome patterns. Despite differences in geography and diet, a shared "microbiome signature" was detected across patients from Israel and Canada.

Featured Neurology Neuroscience Pain Psychology

·May 6, 2025·8 min read

Emotional Regulation Offers a New Path to Relief

A new study shows that improving emotional processing can significantly reduce chronic pain and improve quality of life. Researchers developed Pain and Emotion Therapy, an online intervention teaching emotional regulation, which led to notable pain reduction in participants.

Featured Neurology Neuroscience Pain Psychology

·April 29, 2025·6 min read

Negative Expectations Worsen Pain More Than Positive Ones Ease It

New research shows that negative expectations, known as nocebo effects, exert a stronger and longer-lasting impact on pain perception than positive expectations, or placebo effects. In a two-session study, participants consistently reported more intense pain when they expected worse outcomes, while the benefits of expecting relief were weaker.

Featured Genetics Neurology Neuroscience Pain

·April 23, 2025·4 min read

Clearing Zombie Cells Eases Back Pain

A new preclinical study has found that two drugs—o-Vanillin and RG-7112—can clear “zombie cells” from spinal discs, potentially treating the root cause of chronic low back pain. These senescent cells accumulate with age or injury and cause inflammation, pain, and tissue damage.

Featured Neurology Neuroscience Pain

·April 13, 2025·10 min read

Lab-Grown Nerve Circuit Recreates Human Pain Pathway

Researchers have recreated the human ascending sensory pathway in a lab dish, using organoids that model the key brain and spinal cord regions responsible for transmitting pain. This breakthrough allows scientists to observe how pain signals travel from peripheral neurons to the brain for the first time outside the body.

Featured Neurology Neuroscience Pain

·April 13, 2025·6 min read

Why You Sometimes Don’t Feel Pain Until It’s Too Late

New research highlights how the brain’s own chemistry can suppress pain, explaining why severely injured individuals, like WWII soldiers, sometimes feel little discomfort. The key lies in a brain region called the periaqueductal grey (PAG), which dampens pain signals before they reach conscious awareness.

Featured Neurology Pain

·April 10, 2025·5 min read

Oral Health Tied to Migraines and Fibromyalgia Pain in Women

Poor oral health is significantly linked to increased migraine, abdominal, and musculoskeletal pain in women, particularly those with fibromyalgia. Researchers identified specific oral microbes associated with higher pain scores, highlighting a potential gut-brain-oral microbiome connection.

Featured Neurology Neuroscience Pain

·April 4, 2025·5 min read

Female Hormones Trigger Pain Relief via Immune Cells

Scientists have discovered that female hormones like estrogen and progesterone can trigger immune cells near the spinal cord to release natural opioids, easing pain before it reaches the brain. These immune cells, known as T regulatory cells (T-regs), are located in the meninges and produce the painkilling molecule enkephalin in response to hormonal signals.

Featured Neurology Neuroscience Pain Psychology

·March 19, 2025·5 min read

Rubber Hand Illusion Reduces Pain Perception

A new study shows that the rubber hand illusion can reduce the intensity of pain caused by heat. Researchers found that when participants viewed a rubber hand being illuminated while their hidden hand received a heat stimulus, they reported feeling less pain.

Featured Neurology Neuroscience Pain

·March 15, 2025·5 min read

Nature’s Painkiller: How Virtual Scenes Ease Pain in the Brain

Viewing natural scenes can significantly reduce how people perceive pain, a new neuroimaging study has found. Researchers discovered that participants reported less pain and exhibited altered brain activity associated with pain perception while looking at virtual nature, compared to urban or office environments.

1 2 3 4 5 … 28

Pain

Tylenol Targets Pain Through Unexpected Endocannabinoid Pathway

Century-Old Mystery May Hold the Key to Diabetic Nerve Pain

Gut Microbiome Reveals Chronic Pain Risk, AI Study Finds

Emotional Regulation Offers a New Path to Relief

Negative Expectations Worsen Pain More Than Positive Ones Ease It

Clearing Zombie Cells Eases Back Pain

Lab-Grown Nerve Circuit Recreates Human Pain Pathway

Why You Sometimes Don’t Feel Pain Until It’s Too Late

Oral Health Tied to Migraines and Fibromyalgia Pain in Women

Female Hormones Trigger Pain Relief via Immune Cells

Rubber Hand Illusion Reduces Pain Perception

Nature’s Painkiller: How Virtual Scenes Ease Pain in the Brain

Teenage Cannabis Use Linked to 52% Higher Schizophrenia Risk

Physical Activity Rewires the Traumatized Brain

Gene Linking Schizophrenia to Decision-Making Found

Positive Childhood Experiences and Special Health Care Needs

Subscribe